Close Menu
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
What's Hot

How should we govern nanotechnology?

May 29, 2025

The Future of Needle-Free Immunization

May 28, 2025

Nanoparticle-cell interface enables electromagnetic wireless programming of mammalian transgene expression

May 28, 2025
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
Home»News»Team elucidates mechanism for maximizing therapeutic effects of magnetic nanotherapeutics for cancer
News

Team elucidates mechanism for maximizing therapeutic effects of magnetic nanotherapeutics for cancer

September 29, 2023No Comments3 Mins Read
Facebook Twitter Pinterest Telegram LinkedIn Tumblr WhatsApp Email
Team elucidates mechanism for maximizing therapeutic effects of magnetic nanotherapeutics for cancer
Share
Facebook Twitter LinkedIn Pinterest Telegram Email
Graphical abstract. Credit: ACS Nano (2023). DOI: 10.1021/acsnano.3c03780

A team led by Professor Choi Hong-Soo in the Department of Robotics and Mechatronics Engineering at DGIST has discovered a method to enhance the penetration of magnetic nanoparticles into cancer cells and their magnetic hyperthermia effects through research on chain disassembly and magnetic propulsion mechanisms using a rotational magnetic field.

Published in the journal ACS Nano, their study focused on the delivery of magnetic therapeutic agents using magnetic fields, an area receiving attention in the field of cancer treatment. It is expected to contribute significantly by improving drug delivery efficiency and therapeutic effects in targeted cancer treatments.

Recently, the development of targeted therapeutics that selectively treat cancer cells has been gaining attention in the field of cancer treatment. Among them, research on magnetic carriers that target cancer cells using magnetic fields is underway. However, a problem arises when magnetic nanoparticles are exposed to a uniform magnetic field with a general form; they form long chains in the direction of the magnetic field, making penetration into cancer cells or tumors difficult and reducing the therapeutic efficacy.

In response, the team led by Professor Choi Hong-Soo at DGIST analyzed the interaction between the behavior of magnetic nanoparticles and fluidic viscosity resistance using a unique rotational magnetic field, conducting research on chain disassembly mechanisms that can selectively control magnetic nanoparticle chain lengths.

The research team aimed to verify several factors using a 3D tumor model (tumor spheroids), such as adjusting the length of magnetic nanoparticle chains through a rotational magnetic field, enhanced cellular absorption, and improved magnetic hyperthermia treatment for cancer cells.

See also  New quantum dot approach can enhance electrical conductivity of solar cells

First, the team verified the chain disassembly mechanism of magnetic nanoparticles induced by a rotational magnetic field. Targeting cancer cells and tumor spheroids, they induced increased cellular absorption and penetration by driving magnetic nanoparticles with a rotational magnetic field.

Using fluorescence microscopy for intracellular fluorescent magnetic nanoparticle imaging and transmission electron microscopy for cell and spheroid cross-section observation, they proved that the use of a rotational magnetic field led to the deepest penetration of cells and tumor spheroids compared to the comparison groups (those exposed to a uniform magnetic field and those not exposed to any magnetic field).

Moreover, they induced cancer cell destruction using alternating magnetic fields to confirm the magnetic hyperthermia effects of magnetic nanoparticles in each group. The group with the highest penetration rate due to the rotational magnetic field showed the most effective treatment results. This confirmed that the chain disassembly and magnetic propulsion of magnetic nanoparticles through rotational magnetic fields can enhance cellular absorption, penetration, and ultimately, the therapeutic effects of magnetic nanotherapeutics.

Professor Choi Hong-Soo of DGIST stated, “We have verified that magnetic propulsion through rotational magnetic fields aids in the absorption and penetration of magnetic nanoparticles into cancer cells and tumor spheroids, ultimately improving tumor treatment efficacy. We expect that the technology developed through this research can be widely utilized to enhance therapeutic effects in targeted cancer treatment using magnetic therapeutics.”


Source link

cancer effects elucidates magnetic maximizing mechanism nanotherapeutics Team therapeutic
Share. Facebook Twitter Pinterest LinkedIn Tumblr Email

Related Posts

How should we govern nanotechnology?

May 29, 2025

The Future of Needle-Free Immunization

May 28, 2025

Nanoparticle-cell interface enables electromagnetic wireless programming of mammalian transgene expression

May 28, 2025

Finely-tuned TiO₂ nanorod arrays enhance solar cell efficiency

May 28, 2025

Different DLS-Based Systems Can Give Us Different Size Results

May 27, 2025

2D Janus heterobilayers lead the way

May 27, 2025

Comments are closed.

Top Articles
Research

X-ray Imaging Sheds Light on Fusion Material Challenges

News

Sustainable hydrophobic cellulose shows potential for replacing petroleum-related products

News

Researchers use 2D bimetallic MOFs to create Se-containing electrocatalysts for overall water splitting

Editors Picks

How should we govern nanotechnology?

May 29, 2025

The Future of Needle-Free Immunization

May 28, 2025

Nanoparticle-cell interface enables electromagnetic wireless programming of mammalian transgene expression

May 28, 2025

Finely-tuned TiO₂ nanorod arrays enhance solar cell efficiency

May 28, 2025
About Us
About Us

Your go-to source for the latest nanotechnology breakthroughs. Explore innovations, applications, and implications shaping the future at the molecular level. Stay informed, embrace the nano-revolution.

We're accepting new partnerships right now.

Facebook X (Twitter) Instagram Pinterest
Our Picks

Molybdenene—the ‘metallic’ relative of graphene

September 29, 2023

Still no sign of the promised space elevator, but the material is quietly changing the world

September 29, 2024

Nanowires produce localized highly alkaline microenvironments to kill bacteria

March 23, 2025

Subscribe to Updates

Get the latest creative Nano Tech news from Elnano.com

© 2025 Elnano.com - All rights reserved.
  • Contact
  • Privacy Policy
  • Terms & Conditions

Type above and press Enter to search. Press Esc to cancel.

Cleantalk Pixel