Close Menu
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
What's Hot

2D hybrid material integrates graphene and silica glass for next-generation electronics

June 4, 2025

Zeolite nanopore model links crystal size to metal cluster migration and catalyst performance

June 4, 2025

Spontaneous symmetry breaking in electron systems proves elusive

June 3, 2025
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
Home»News»Study finds protein reduces toxicity of graphene oxide for drug delivery
News

Study finds protein reduces toxicity of graphene oxide for drug delivery

August 22, 2024No Comments3 Mins Read
Facebook Twitter Pinterest Telegram LinkedIn Tumblr WhatsApp Email
Share
Facebook Twitter LinkedIn Pinterest Telegram Email
Protein reduces toxicity of drug-delivery material made of graphite
Investigating protein corona-dependent toxicity of GO nanosheets in immunocompetent and immunodeficient mice. Credit: ACS Nano (2024). DOI: 10.1021/acsnano.4c08561

A new study has discovered ways to reduce the toxicity of graphene oxide (GO), an ultra-thin sheet of nanomaterial derived from graphite, laying the groundwork to use it as a drug delivery system.

Professor Khuloud Al-Jamal, who led the study, said, “Researchers have been incredibly excited in the potential medical applications of graphene since experiments into the nanomaterial were recognized with the Nobel Prize in Physics in 2010. However, concerns around toxicity have remained a consistent obstacle.”

“In this study, we introduced chemical methods to make GO more biofriendly and unraveled the link between proteins in the corona and GO’s safety profile. Most importantly, we showed that in silico methods could accurately predict toxicity in mice offering ways to substitute the use of animals. I am proud of this cross-continent team effort between UK, Hong Kong, China and the U.S.,” said Professor Al-Jamal, Professor of Drug Delivery & Nanomedicine and Head of Medicines Development.

Graphene oxide (GO) is an ultra-thin sheet derived from graphite. It is similar to pencil lead but includes attached oxygen atoms, making it compatible with water. Its unique physical and chemical properties mean it has a high capacity for carrying antibiotics and anticancer drugs, among others, as well as targeting specific cells, making it a potentially effective drug delivery system.

When GO enters the body, it interacts with proteins found in biological fluids like plasma and cerebrospinal fluid. This interaction leads to the formation of a hardened coating of proteins—otherwise known as a protein corona—around the GO that influences the behavior and toxicity of the nanomaterial.

See also  High-Shear Mixing and High-Pressure Homogenization

Therefore, to safely take advantage of this drug delivery system, significant research is required to alter the GO surface, or its delivery method, and alleviate its toxic effect inside the body.

A new multidisciplinary study, published in ACS Nano, was able to reveal the circumstances that cause the corona to drive toxicity. Using this knowledge, the researchers subsequently investigated and identified proteins in the corona that successfully mitigated GO toxicity, creating potential for its use as a drug delivery system and laying the groundwork for injectables and implants made from nanomaterials.

Two types of GO sheets with new chemical modifications were tested to see how they bind to the corona protein, and their impact on the wider body. Results from mice models showed that sheets with a low protein coating caused more severe damage to the liver and lungs, as well as signs of increased molecular markers of inflammation and blood toxicity. This was most apparent in mice models with normal, functioning immune systems.

Detailed analysis of the findings allowed the researchers to identify consistent patterns linking the protein coatings to their toxic effects in mice. They found that increased quantity of the corona led to reduced toxicity from the GO, with further analysis identifying key proteins within it that could also mitigate the toxicity of the nanomaterial.

This multidisciplinary approach, comprising chemistry, 2D materials, proteomics, mathematical modeling and animal research is a major step forward for the potential practical application of GO as a drug delivery system and other nanomaterials.

Provided by
King’s College London


See also  Researchers wire up individual graphene nanoribbons


Source link

Share. Facebook Twitter Pinterest LinkedIn Tumblr Email

Related Posts

2D hybrid material integrates graphene and silica glass for next-generation electronics

June 4, 2025

Zeolite nanopore model links crystal size to metal cluster migration and catalyst performance

June 4, 2025

Spontaneous symmetry breaking in electron systems proves elusive

June 3, 2025

Improving Crop Tolerance to Drought and Heat Using Nanomaterials

June 3, 2025

Crystal-modifying agent piracetam provides scalable strategy for high-efficiency all-perovskite tandem solar cells

June 3, 2025

Phonon decoupling in naturally occurring mineral enables subatomic ferroelectric memory

June 2, 2025

Comments are closed.

Top Articles
News

Scientists develop antiviral color nanocoating technology

News

The Investigation and Optimization Piezo Actuators and Photodiodes

News

Mineral nanoparticles could potentially act as nanozyme mimics, assisting fungi in breaking down organic pollutants

Editors Picks

2D hybrid material integrates graphene and silica glass for next-generation electronics

June 4, 2025

Zeolite nanopore model links crystal size to metal cluster migration and catalyst performance

June 4, 2025

Spontaneous symmetry breaking in electron systems proves elusive

June 3, 2025

Improving Crop Tolerance to Drought and Heat Using Nanomaterials

June 3, 2025
About Us
About Us

Your go-to source for the latest nanotechnology breakthroughs. Explore innovations, applications, and implications shaping the future at the molecular level. Stay informed, embrace the nano-revolution.

We're accepting new partnerships right now.

Facebook X (Twitter) Instagram Pinterest
Our Picks

Nanomaterials are emerging as a powerful tool for coastal oil spill cleanup

February 15, 2025

Spraying rice with sunscreen particles during heat waves boosts growth

November 5, 2024

Molecular nanocages can remove 80–90% of PFAS from water

April 23, 2025

Subscribe to Updates

Get the latest creative Nano Tech news from Elnano.com

© 2025 Elnano.com - All rights reserved.
  • Contact
  • Privacy Policy
  • Terms & Conditions

Type above and press Enter to search. Press Esc to cancel.

Cleantalk Pixel