Close Menu
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
What's Hot

Naturally derived nanoparticles show promise against cardiovascular and kidney disease

June 6, 2025

Ballistic electrons chart a new course for next-gen terahertz devices

June 6, 2025

‘Stealthy’ lipid nanoparticles give mRNA vaccines a makeover

June 5, 2025
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
Home»News»‘Russian doll’ packaging could boost drug delivery
News

‘Russian doll’ packaging could boost drug delivery

August 7, 2024No Comments3 Mins Read
Facebook Twitter Pinterest Telegram LinkedIn Tumblr WhatsApp Email
Share
Facebook Twitter LinkedIn Pinterest Telegram Email
'Russian doll' packaging developed at imperial could boost drug delivery
Engineering nanoscale liposomes-in-liposomes. Credit: Nature Chemistry (2024). DOI: 10.1038/s41557-024-01584-z

New technology, which is in the early stages of development, has the potential to significantly enhance the effectiveness and reduce the side effects of drugs and vaccines.

The work is published in the journal Nature Chemistry.

Drugs and vaccines can be delivered to the body using tiny packages called nanoparticles. The structures of these delivery particles are surprisingly simple, typically consisting of basic spherical clusters in which the drug or vaccine is held, before being released into the body. However, it is thought that more intricate architectures might provide more sophisticated properties, enhancing the efficacy and duration of therapeutics.

To address this, researchers at Imperial College London developed a new technology that lets them create compartments within compartments on the nanoscale. These compartments can mean timing drug release for maximum effect at the site it’s most needed. Timed release can make drugs and vaccines better targeted to specific sites of the body, which could increase their efficacy and reduce potential side effects.

Lead researcher Dr. Yuval Elani, of Imperial College London’s Department of Chemical Engineering, said, “Much like Russian dolls, our technology allows us to form particle-in-particle structures, with the ability to control all features of the particles, including the drug or vaccine encapsulated within each one. With further research to study how these nanoparticles interact with live organisms, this advancement holds significant potential for revolutionizing both therapeutics, such as chemotherapies, and vaccines.”

Inspired by nature’s cells

The researchers drew inspiration from the structural complexity of living cells. Dr. Elani said, “Just as the structural complexity of animal cells makes them capable of sophisticated functions, compartmentalized nanoparticles can be tweaked to exhibit more advanced features too.”

See also  Modular protein adapter technology enables exosome-based precision drug delivery

The designer nanoparticles are capable of multi-stage release, which allows one or two separate drugs to be delivered and released from the particle in several discrete bursts following one administration. This could replace the need for two or three separate vaccine shots spaced days apart.

They can also simultaneously release two different drugs, which could be crucial for combination therapies or adjuvant vaccine systems, where one molecule stimulates the immune response while another acts as the therapeutic agent itself.

The nanoparticles could also be engineered to create new drugs inside itself, triggered by encountering stimuli such a specific disease. This approach could enhance the therapeutic potential of the drug and reduce side effects, leading to better therapies and opening new avenues for patient treatment and care.

While the initial findings to demonstrate the feasibility of the technology are promising, the researchers say that it is currently at the proof-of-concept stage and has not yet been tested in an organism. Further research and development are needed to translate these findings into practical applications, including the testing and validating the system with actual drugs and vaccines in animal models to fully assess its efficacy and safety for medical use.

First author Dr. Colin Pilkington, from Imperial’s Department of Chemical Engineering, said, “There is a lot of buzz around lipid nanoparticle-based solutions to drug delivery. We hope this work will inspire others to consider more structurally diverse nanoparticle architectures, and that some of the ideas we have explored prove useful to the wider scientific community.”

See also  Controlling quantum light at room temperature with tunable nanostructures and low voltage

Provided by
Imperial College London



Source link

Share. Facebook Twitter Pinterest LinkedIn Tumblr Email

Related Posts

Naturally derived nanoparticles show promise against cardiovascular and kidney disease

June 6, 2025

Ballistic electrons chart a new course for next-gen terahertz devices

June 6, 2025

‘Stealthy’ lipid nanoparticles give mRNA vaccines a makeover

June 5, 2025

Single-layer waveguide display uses achromatic metagratings for more compact augmented reality eyewear

June 5, 2025

2D hybrid material integrates graphene and silica glass for next-generation electronics

June 4, 2025

Zeolite nanopore model links crystal size to metal cluster migration and catalyst performance

June 4, 2025

Comments are closed.

Top Articles
News

Electrically defined quantum dots in zinc oxide

News

Developing nanocatalysts to overcome limitations of water electrolysis technology

News

Charge travels like light in bilayer graphene

Editors Picks

Naturally derived nanoparticles show promise against cardiovascular and kidney disease

June 6, 2025

Ballistic electrons chart a new course for next-gen terahertz devices

June 6, 2025

‘Stealthy’ lipid nanoparticles give mRNA vaccines a makeover

June 5, 2025

Single-layer waveguide display uses achromatic metagratings for more compact augmented reality eyewear

June 5, 2025
About Us
About Us

Your go-to source for the latest nanotechnology breakthroughs. Explore innovations, applications, and implications shaping the future at the molecular level. Stay informed, embrace the nano-revolution.

We're accepting new partnerships right now.

Facebook X (Twitter) Instagram Pinterest
Our Picks

Ocean environment safety of nanocellulose investigated in study of mussels

April 21, 2024

New mass spectrometry technology could transform tiny sample analysis

September 16, 2024

A microchip designed to transform the production of mRNA therapeutics and vaccines

September 2, 2023

Subscribe to Updates

Get the latest creative Nano Tech news from Elnano.com

© 2025 Elnano.com - All rights reserved.
  • Contact
  • Privacy Policy
  • Terms & Conditions

Type above and press Enter to search. Press Esc to cancel.

Cleantalk Pixel