Close Menu
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
What's Hot

2D hybrid material integrates graphene and silica glass for next-generation electronics

June 4, 2025

Zeolite nanopore model links crystal size to metal cluster migration and catalyst performance

June 4, 2025

Spontaneous symmetry breaking in electron systems proves elusive

June 3, 2025
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
Home»News»Researchers test curcumin nanoemulsion for treatment of intestinal inflammation
News

Researchers test curcumin nanoemulsion for treatment of intestinal inflammation

March 17, 2024No Comments3 Mins Read
Facebook Twitter Pinterest Telegram LinkedIn Tumblr WhatsApp Email
Researchers test curcumin nanoemulsion for treatment of intestinal inflammation
Share
Facebook Twitter LinkedIn Pinterest Telegram Email
Graphical abstract. Credit: International Journal of Pharmaceutics (2023). DOI: 10.1016/j.ijpharm.2023.123683

A nanoemulsion containing particles of curcumin, which is known to have anti-inflammatory and antioxidant properties, has been found capable of modulating the gut microbiota of mice with intestinal inflammation in experiments conducted by researchers at the University of Western São Paulo (UNOESTE) and São Paulo State University (UNESP) in Brazil.

The study is published in the International Journal of Pharmaceutics.

Curcumin, a natural substance belonging to the group of bioactive compounds called curcuminoids, is a yellow polyphenolic pigment found in the turmeric plant (Curcuma longa). It has gained prominence in treatments to combat inflammatory intestinal disorders, but its bioavailability is low when it is administered orally. This problem is exacerbated in patients with Crohn’s disease, ulcerative colitis and other conditions associated with inflammation of the digestive tract and gut microbiota alterations.

To enhance the efficacy of curcumin in such cases, the scientists developed an emulsion containing nanoparticles of the compound (invisible to the naked eye).

“The research comprised two stages. The first entailed producing a nanoemulsion to deliver the curcumin. In the second, we evaluated its stability, morphology and physicochemical properties,” said Lizziane Kretli Winkelströter Eller, last author of the article and a professor at UNOESTE.

Next, to test the action of the nanoemulsion in mice, the researchers induced intestinal inflammation using a drug called indomethacin and administered the nanoemulsion orally for 14 days. At the end of this period, they evaluated the intestinal inflammation by macroscopic, histopathological and metagenomic analysis.

The results showed that the nanoemulsion effectively improved the bioavailability of curcumin and modulated the gut microbiota of the mice after the damage was caused by the drug, increasing the presence there of beneficial bacteria.

See also  Nanotech reveals how harmful microplastics stick to coral reefs

“The nanoemulsion didn’t lead to a significant improvement in the intestinal inflammation, but the relative abundance of Lactobacillus bacteria was about 25% higher in the mice treated with curcumin nanoemulsion than in the control group,” Eller said.

The authors of the study, the first to measure the effects of curcumin nanoemulsion in this way, stressed the importance of developing novel formulations that enhance the efficacy of curcumin in preventing and treating inflammatory bowel disease, since it has proved to be a valid alternative to existing treatments, which are expensive and have significant side effects.

The group continues to conduct research on the potential of nanoformulations to deliver nutraceuticals (food elements of plant or animal origin with significant health benefits).

“Specifically with regard to the curcumin nanoemulsion, we’re adjusting the formulation to increase the bioavailability of the active ingredient and will soon apply it in other protocols for the prevention and treatment of intestinal damage,” Eller said.


Source link

curcumin inflammation intestinal nanoemulsion Researchers test Treatment
Share. Facebook Twitter Pinterest LinkedIn Tumblr Email

Related Posts

2D hybrid material integrates graphene and silica glass for next-generation electronics

June 4, 2025

Zeolite nanopore model links crystal size to metal cluster migration and catalyst performance

June 4, 2025

Spontaneous symmetry breaking in electron systems proves elusive

June 3, 2025

Improving Crop Tolerance to Drought and Heat Using Nanomaterials

June 3, 2025

Crystal-modifying agent piracetam provides scalable strategy for high-efficiency all-perovskite tandem solar cells

June 3, 2025

Phonon decoupling in naturally occurring mineral enables subatomic ferroelectric memory

June 2, 2025

Comments are closed.

Top Articles
News

New process creates ordered semiconductor material at room temperature

Researchers fabricate the world’s smallest QR code using infrared information carrier

News

Nanoscale spectroscopy detects vibrational signals from molecules in confined gaps

Editors Picks

2D hybrid material integrates graphene and silica glass for next-generation electronics

June 4, 2025

Zeolite nanopore model links crystal size to metal cluster migration and catalyst performance

June 4, 2025

Spontaneous symmetry breaking in electron systems proves elusive

June 3, 2025

Improving Crop Tolerance to Drought and Heat Using Nanomaterials

June 3, 2025
About Us
About Us

Your go-to source for the latest nanotechnology breakthroughs. Explore innovations, applications, and implications shaping the future at the molecular level. Stay informed, embrace the nano-revolution.

We're accepting new partnerships right now.

Facebook X (Twitter) Instagram Pinterest
Our Picks

Scientists propose method that imparts elastic recovery to ferroelectric materials

August 9, 2023

High-quality nanodiamonds offer new bioimaging and quantum sensing potential

January 4, 2025

Propeller shape helps direct nanoparticles, researchers say

December 15, 2023

Subscribe to Updates

Get the latest creative Nano Tech news from Elnano.com

© 2025 Elnano.com - All rights reserved.
  • Contact
  • Privacy Policy
  • Terms & Conditions

Type above and press Enter to search. Press Esc to cancel.

Cleantalk Pixel