Close Menu
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
What's Hot

A new molecular model of bilayer graphene with higher semiconducting properties

May 31, 2025

5 Nanomaterial Innovations That Didn’t Deliver (Yet)

May 30, 2025

Scientists identify new 2D copper boride material with unique atomic structure

May 30, 2025
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
Home»News»Researchers introduce singlet oxygen battery for battling multidrug-resistant pathogens
News

Researchers introduce singlet oxygen battery for battling multidrug-resistant pathogens

August 21, 2023No Comments3 Mins Read
Facebook Twitter Pinterest Telegram LinkedIn Tumblr WhatsApp Email
Researchers introduce singlet oxygen battery for battling multidrug-resistant pathogens
Share
Facebook Twitter LinkedIn Pinterest Telegram Email
Credit: Angewandte Chemie International Edition (2023). DOI: 10.1002/anie.202306803

In antibacterial photodynamic therapy, irradiation is used to produce reactive oxygen species that kill off bacteria. Because it requires external light and oxygen, this method is only suitable for surface infections.

In the journal Angewandte Chemie, a Chinese research team has now introduced a molecular “singlet oxygen battery” that can be “charged” with reactive oxygen, which it then releases in deep tissue layers to target methicillin-resistant staphylococcus.

Antibiotic-resistant bacteria are on the rise. Though often harmless to healthy people, dreaded multidrug-resistant “hospital pathogens” such as methicillin-resistant Staphylococcus aureus (MRSA) use injuries or fresh surgical wounds to gain entry to the body. They also infect immunocompromised patients. Because antibiotics are not effective, there is sometimes no remedy.

One highly promising alternative is antibacterial photodynamic therapy, which is already widely used in dentistry. In this technique, a light-activated substance (photosensitizer) is irradiated, triggering a photodynamic reaction that produces singlet oxygen (1O2), an excited form of oxygen.

Unlike antibiotics, this substance simultaneously attacks multiple biomolecular sites on the bacteria. It is easy to use, safe, painless, and generally free of side effects. Unfortunately, it has only been useful for surface infections because the necessary light only penetrates a few millimeters into the tissue. Additionally deeper tissue layers also do not have enough oxygen for effective treatment.

A team led by Bingran Yu and Fu-Jian Xu at Beijing University of Chemical Technology has now developed a new approach to photodynamic therapy: a “singlet oxygen battery” that can be used to fight deep bacterial infections because it requires neither light nor external oxygen.

See also  Researchers develop photoactivatable nanomedicine for the treatment of age-related macular degeneration

The conversion of oxygen into reactive singlet oxygen through irradiation in the presence of a molecule that captures light (photosensitizer) happens first. The “battery” is “charged” with the singlet oxygen. This “battery” consists of a special nitrogen-containing, six-membered ring of carbon atoms (pyridone) that tightly binds the singlet oxygen.

The reactive oxygen molecule bridges two opposite vertices of the ring (endoperoxide). A peptide bound to the ring specifically “recognizes” MRSA bacteria, so the molecular batteries accumulate around and in the bacteria and continuously release their singlet oxygen.

The bacteria are thus simultaneously attacked at many different locations, including their membrane, DNA, enzymes, and other proteins. This makes the development of resistance virtually impossible. When administered to mice through nebulization, the singlet oxygen battery was shown to be very effective in treating pulmonary infections caused by MRSA. Systemic side effects were not observed.


Source link

battery battling introduce multidrugresistant oxygen pathogens Researchers singlet
Share. Facebook Twitter Pinterest LinkedIn Tumblr Email

Related Posts

A new molecular model of bilayer graphene with higher semiconducting properties

May 31, 2025

5 Nanomaterial Innovations That Didn’t Deliver (Yet)

May 30, 2025

Scientists identify new 2D copper boride material with unique atomic structure

May 30, 2025

Nanoscale biosensor lets scientists monitor molecules in real time

May 30, 2025

How should we govern nanotechnology?

May 29, 2025

The Future of Needle-Free Immunization

May 28, 2025

Comments are closed.

Top Articles

Opposites Attract, Likes Repel? Scientists Overturn Fundamental Principle of Physics

News

The Effect of Heat Treatment on Chitosan Nanocomposites

News

New device precisely controls photon emission for more efficient portable screens

Editors Picks

A new molecular model of bilayer graphene with higher semiconducting properties

May 31, 2025

5 Nanomaterial Innovations That Didn’t Deliver (Yet)

May 30, 2025

Scientists identify new 2D copper boride material with unique atomic structure

May 30, 2025

New contact lenses allow wearers to see in the near-infrared

May 30, 2025
About Us
About Us

Your go-to source for the latest nanotechnology breakthroughs. Explore innovations, applications, and implications shaping the future at the molecular level. Stay informed, embrace the nano-revolution.

We're accepting new partnerships right now.

Facebook X (Twitter) Instagram Pinterest
Our Picks

Using Graphene Field Effect Transistors in Biosensors

June 6, 2024

New wind speed sensor uses minimal power for advanced weather tracking

June 3, 2024

Targeted nanoparticles show promise for more effective antifungal treatments

May 23, 2025

Subscribe to Updates

Get the latest creative Nano Tech news from Elnano.com

© 2025 Elnano.com - All rights reserved.
  • Contact
  • Privacy Policy
  • Terms & Conditions

Type above and press Enter to search. Press Esc to cancel.

Cleantalk Pixel