Close Menu
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
What's Hot

Controlling contaminants inside nanopores holds promise for desalination, carbon dioxide storage and porous catalysts

May 22, 2025

Modified glass fiber microstructure could illuminate blood vessel health from within

May 21, 2025

A recently realized ferroelectric topology in nanomembranes enables light field manipulation

May 21, 2025
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
Home»News»Researchers develop miRNA-tunable living interface for neurovascular remodeling
News

Researchers develop miRNA-tunable living interface for neurovascular remodeling

December 2, 2024No Comments2 Mins Read
Facebook Twitter Pinterest Telegram LinkedIn Tumblr WhatsApp Email
Researchers develop miRNA-tunable living interface for neurovascular remodeling
Share
Facebook Twitter LinkedIn Pinterest Telegram Email
Design of the LIFES. LIFES imparts topographical, piezoelectric, and photo-pyroelectric signals for cell modulation, enabling fine-tuned exosome secretion, which facilitates neurovascular remodeling. Credit: SIAT

A research team led by Dr. Du Xuemin from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences has reported a living interface with unique functionalities of durable secretion of bioactive exosomes with tunable contents and miRNA cargoes, effectively promoting neurovascular remodeling.

The study was published in Matter on Nov. 21.

Neurovascular remodeling is crucial for restoring normal functions of regenerated tissues or engineered organs, which requires multi-target and phase-specific paracrine regulation. However, existing strategies still cannot mimic such dynamic and complicated paracrine regulation effects in the native physiological processes, hindering synergistic neurovascular remodeling.

Exosomes, as key entities in the native paracrine process, show great promise for neurovascular remodeling yet still face challenges. Direct exosome administration is limited by its short lifetime (24–48 hours). In addition, exosome delivery systems struggle with preserving bioactivity and maintaining adaptable miRNA cargoes throughout the entire release period, limiting their effectiveness at different stages of neurovascular remodeling.

The proposed living interface in this study for fine-tuned exosome secretion (LIFES) consists of two core elements, a poly(vinylidene fluoride-co-trifluoro ethylene)-based intelligent material layer with rationally designed topographical structures and superior electric properties for cell modulation, and a living cell layer with rat bone marrow-derived mesenchymal stem cells (MSCs) for efficient biogenesis of exosomes.

Through the synergistic interactions between the two core elements, LIFES can secrete bioactive exosomes in sustained (~192 hours) and phase-specific manners, with tunable contents (~8-fold increases) and programmable miRNA cargoes (initially pro-angiogenic and later pro-neurogenic).

“The phase-specific exosome secretion of LIFES meets physiological requirements, which aligns with the native multi-target and multi-stage paracrine regulation effects observed in physiological neurovascular remodeling processes,” said Dr. Du.

See also  What is Quantum Mechanical Modeling?

By mimicking the natural paracrine regulation effects within the native physiological processes of neurovascular remodeling, LIFES effectively promotes the reconstituting of vascular neural networks, even in challenging diabetic wound models.

The study will open new avenues for next-generation intelligent materials, revolutionizing biomedical devices, regenerative medicine, and brain-machine interfaces.

Provided by
Chinese Academy of Sciences



Source link

develop interface living miRNAtunable neurovascular remodeling Researchers
Share. Facebook Twitter Pinterest LinkedIn Tumblr Email

Related Posts

Controlling contaminants inside nanopores holds promise for desalination, carbon dioxide storage and porous catalysts

May 22, 2025

Modified glass fiber microstructure could illuminate blood vessel health from within

May 21, 2025

A recently realized ferroelectric topology in nanomembranes enables light field manipulation

May 21, 2025

How AI is Automating Scanning Probe Microscopy

May 20, 2025

Stability solution brings unique form of carbon closer to practical application

May 20, 2025

Flux Tools for Drift Conditions

May 20, 2025

Comments are closed.

Top Articles
News

Precisely arranging nanoparticles to develop plasmonic molecules

News

A ferroelectric dimeric liquid crystal with huge spontaneous polarization and dielectric constant at low temperatures

News

Electricity generation on the nanoscale

Editors Picks

Controlling contaminants inside nanopores holds promise for desalination, carbon dioxide storage and porous catalysts

May 22, 2025

Modified glass fiber microstructure could illuminate blood vessel health from within

May 21, 2025

A recently realized ferroelectric topology in nanomembranes enables light field manipulation

May 21, 2025

How AI is Automating Scanning Probe Microscopy

May 20, 2025
About Us
About Us

Your go-to source for the latest nanotechnology breakthroughs. Explore innovations, applications, and implications shaping the future at the molecular level. Stay informed, embrace the nano-revolution.

We're accepting new partnerships right now.

Facebook X (Twitter) Instagram Pinterest
Our Picks

Chiro-optical force observed at the nanoscale

October 14, 2023

Nanopore-based sensors could transform diagnostics

January 9, 2025

Scientists propose theoretical design strategy for room-temperature metal-organic multiferroics

April 6, 2024

Subscribe to Updates

Get the latest creative Nano Tech news from Elnano.com

© 2025 Elnano.com - All rights reserved.
  • Contact
  • Privacy Policy
  • Terms & Conditions

Type above and press Enter to search. Press Esc to cancel.

Cleantalk Pixel