Close Menu
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
What's Hot

New insights show universal applicability of carbyne as a sensor

May 31, 2025

A new molecular model of bilayer graphene with higher semiconducting properties

May 31, 2025

5 Nanomaterial Innovations That Didn’t Deliver (Yet)

May 30, 2025
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
Home»Medical»Research reveals crucial role of saturated fatty acids in memory creation process
Medical

Research reveals crucial role of saturated fatty acids in memory creation process

February 6, 2024No Comments3 Mins Read
Facebook Twitter Pinterest Telegram LinkedIn Tumblr WhatsApp Email
Research reveals crucial role of saturated fatty acids in memory creation process
Share
Facebook Twitter LinkedIn Pinterest Telegram Email

Researchers at the University of Queensland have revealed the crucial role of saturated fatty acids in the brain’s consolidation of memories. 

Dr Isaac Akefe from UQ’s Queensland Brain Institute has uncovered the molecular mechanism and identified the genes underlying the memory creation process, opening the door to a potential treatment for neurodegenerative disorders. 

We’ve shown previously that levels of saturated fatty acids increase in the brain during neuronal communication, but we didn’t know what was causing these changes.

Now for the first time, we’ve identified alterations in the brain’s fatty acid landscape when the neurons encode a memory.

An enzyme called Phospholipase A1 (PLA1) interacts with another protein at the synapse called STXBP1 to form saturated fatty acids.”

Dr Isaac Akefe from UQ’s Queensland Brain Institute

The brain is the body’s fattiest organ, with fatty compounds called lipids making up 60% of its weight. Fatty acids are the building blocks of a class of lipids called phospholipids.

The work done in Professor Frederic Meunier’s laboratory has shown that STXBP1 controls the targeting of the PLA1 enzyme, coordinating the release of fatty acids and directing communication at the synapses in the brain.

“Human mutations in the PLA1 and the STXBP1 genes reduce free fatty acid levels and promote neurological disorders,” Professor Meunier said.

“To determine the importance of free fatty acids in memory formation, we used mouse models where the PLA1 gene is removed.

“We tracked the onset and progression of neurological and cognitive decline throughout their lives.

See also  EPFL researchers achieve near-perfect control of individual molecules for improving sensing precision

“We saw that even before their memories became impaired, their saturated free fatty acid levels were significantly lower than control mice.

“This indicates that this PLA1 enzyme, and the fatty acids it releases, play a key role in memory acquisition.”

The research has important implications for understanding of how memories are formed.

“Our findings indicate that manipulating this memory acquisition pathway has exciting potential as a treatment for neurodegenerative diseases, such as Alzheimer’s,” Professor Meunier said.

The research team acknowledges the contributions of PhD candidates Saber Abd Elkader from the Australian Institute for Bioengineering and Nanotechnology, and Benjamin Matthews from the Queensland Brain Institute.

This is a collaborative study with the University of New South Wales, University of Strasbourg, University of Bordeaux, The Scripp Research Institute and the Baylor College of Medicine.

The research paper is published in the EMBO Journal.

Source:

Journal reference:

O Akefe, I., et al. (2024) The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids. The EMBO Journal. doi.org/10.1038/s44318-024-00030-7.

Source link

acids creation Crucial fatty memory process Research reveals Role saturated
Share. Facebook Twitter Pinterest LinkedIn Tumblr Email

Related Posts

Dual-mode MRI nanoprobe mimics biological processes to pinpoint early fibrosis in fatty liver disease

May 1, 2025

The Role of Nanotechnology in Plant Genome Editing

April 8, 2025

Ultrafast X-ray study reveals solvation suppresses electronic rearrangement in pyrazine

April 3, 2025

The Evolving Role of Nanogels in Drug Delivery: New Developments

April 1, 2025

Study reveals controlled proton tunneling in water trimers

March 28, 2025

The Role of Nanosponges in Oil Spill Cleanup

March 13, 2025

Comments are closed.

Top Articles
News

Researchers develop tiny droplets that harness laser light to detect disease markers

News

Bacteria ‘nanowires’ could help develop green electronics

News

Genetically engineered cell therapies with mRNA lipid nanoparticles for transferrable platelets

Editors Picks

New insights show universal applicability of carbyne as a sensor

May 31, 2025

A new molecular model of bilayer graphene with higher semiconducting properties

May 31, 2025

5 Nanomaterial Innovations That Didn’t Deliver (Yet)

May 30, 2025

Scientists identify new 2D copper boride material with unique atomic structure

May 30, 2025
About Us
About Us

Your go-to source for the latest nanotechnology breakthroughs. Explore innovations, applications, and implications shaping the future at the molecular level. Stay informed, embrace the nano-revolution.

We're accepting new partnerships right now.

Facebook X (Twitter) Instagram Pinterest
Our Picks

New mass spectrometry technology could transform tiny sample analysis

September 16, 2024

Researchers propose an organic-solvent-free method for producing nanosized vaterite

November 17, 2023

Navigating the Future of Neuromorphic Computing

November 14, 2023

Subscribe to Updates

Get the latest creative Nano Tech news from Elnano.com

© 2025 Elnano.com - All rights reserved.
  • Contact
  • Privacy Policy
  • Terms & Conditions

Type above and press Enter to search. Press Esc to cancel.

Cleantalk Pixel