Close Menu
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
What's Hot

Naturally derived nanoparticles show promise against cardiovascular and kidney disease

June 6, 2025

Ballistic electrons chart a new course for next-gen terahertz devices

June 6, 2025

‘Stealthy’ lipid nanoparticles give mRNA vaccines a makeover

June 5, 2025
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
Home»News»New nanotech weapon takes aim at hard-to-treat breast cancer
News

New nanotech weapon takes aim at hard-to-treat breast cancer

September 21, 2023No Comments2 Mins Read
Facebook Twitter Pinterest Telegram LinkedIn Tumblr WhatsApp Email
New nanotech weapon takes aim at hard-to-treat breast cancer
Share
Facebook Twitter LinkedIn Pinterest Telegram Email
Credit: Nanoscale (2023). DOI: 10.1039/D3NR00196B

Breast cancer in its various forms affects more than 250,000 Americans a year. One particularly aggressive and hard-to-treat type is triple-negative breast cancer (TNBC), which lacks specific receptors targeted by existing treatments. The rapid growth and metastasis of this cancer also make it challenging to manage, leading to limited therapy options and an often poor prognosis for patients.

A promising new approach that uses minuscule tubes to deliver cancer-fighting drugs directly to the tumor site while preserving healthy cells has been developed by Johns Hopkins engineers. The team’s research appeared in Nanoscale.

“In this paper, we showed that we can use nanotubes to specifically target both proliferating and senescent TNBC cells with chemotherapeutics and senolytics, killing them without targeting healthy breast cells,” said Efie Kokkoli, professor of chemical and biomolecular engineering, a core researcher at the Johns Hopkins Institute for NanoBioTechnology, and a specialist in engineering targeted nanoparticles for the delivery of cancer therapeutics.

Senescent cancer cells are those that, after exposure to chemotherapy, stop multiplying and are resistant to further treatment. Senolytics are the medications that target and eliminate them.

To create the tubes, Kokkoli’s team used single-stranded DNA (ssDNA)-amphiphiles—structures that are designed to stick to molecules like water and can self-assemble into hollow nanotubes.

The team loaded the nanotubes with either the chemotherapeutic doxorubicin or the senolytic ABT-263. Nanotubes with ABT-263 effectively killed senescent cancer cells, making them more susceptible to further treatment from doxorubicin.

This new approach that combines the therapeutic properties of both chemotherapeutics and senolytics delivered through the novel DNA nanotubes has the potential to change how TNBC and other cancers are treated as it offers a direct way to fight resistant cancers, according to Kokkoli.

See also  Using metal ion-linked nanostructures to improve immune response and boost breast tumor treatment

“Our ssDNA nanotubes are a promising delivery vehicle that could be used for targeted delivery of therapeutics to TNBC and other cancer cells, and even though we have not started this yet, the next logical step for us is to evaluate this delivery system in animal studies and evaluate them in a mouse model of TNBC,” Kokkoli said.

Provided by
Johns Hopkins University



Source link

aim breast cancer hardtotreat Nanotech Takes weapon
Share. Facebook Twitter Pinterest LinkedIn Tumblr Email

Related Posts

Naturally derived nanoparticles show promise against cardiovascular and kidney disease

June 6, 2025

Ballistic electrons chart a new course for next-gen terahertz devices

June 6, 2025

‘Stealthy’ lipid nanoparticles give mRNA vaccines a makeover

June 5, 2025

Single-layer waveguide display uses achromatic metagratings for more compact augmented reality eyewear

June 5, 2025

2D hybrid material integrates graphene and silica glass for next-generation electronics

June 4, 2025

Zeolite nanopore model links crystal size to metal cluster migration and catalyst performance

June 4, 2025

Comments are closed.

Top Articles

‘Stealthy’ lipid nanoparticles give mRNA vaccines a makeover

News

Team elucidates mechanism for maximizing therapeutic effects of magnetic nanotherapeutics for cancer

Research

Nanotechnology in Agriculture: Feeding the Future

Editors Picks

Naturally derived nanoparticles show promise against cardiovascular and kidney disease

June 6, 2025

Ballistic electrons chart a new course for next-gen terahertz devices

June 6, 2025

‘Stealthy’ lipid nanoparticles give mRNA vaccines a makeover

June 5, 2025

Single-layer waveguide display uses achromatic metagratings for more compact augmented reality eyewear

June 5, 2025
About Us
About Us

Your go-to source for the latest nanotechnology breakthroughs. Explore innovations, applications, and implications shaping the future at the molecular level. Stay informed, embrace the nano-revolution.

We're accepting new partnerships right now.

Facebook X (Twitter) Instagram Pinterest
Our Picks

Tiny tech with big potential

September 12, 2024

Nanoparticles demonstrate new and unexpected mechanism of coronavirus disinfection

February 11, 2025

Researchers develop high-quality nanomechanical resonators with built-in piezoelectricity

November 14, 2024

Subscribe to Updates

Get the latest creative Nano Tech news from Elnano.com

© 2025 Elnano.com - All rights reserved.
  • Contact
  • Privacy Policy
  • Terms & Conditions

Type above and press Enter to search. Press Esc to cancel.

Cleantalk Pixel