Close Menu
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
What's Hot

New insights show universal applicability of carbyne as a sensor

May 31, 2025

A new molecular model of bilayer graphene with higher semiconducting properties

May 31, 2025

5 Nanomaterial Innovations That Didn’t Deliver (Yet)

May 30, 2025
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
Home»Medical»New nanoparticle-based system developed for comprehensive treatment of rheumatoid arthritis
Medical

New nanoparticle-based system developed for comprehensive treatment of rheumatoid arthritis

October 27, 2023No Comments4 Mins Read
Facebook Twitter Pinterest Telegram LinkedIn Tumblr WhatsApp Email
New nanoparticle-based system developed for comprehensive treatment of rheumatoid arthritis
Share
Facebook Twitter LinkedIn Pinterest Telegram Email

A team of scientists led by KOO Sagang from the Seoul National University and Center for Nanoparticle Research within the Institue for Basic Science Center (IBS), in collaboration with researchers from Korea Institute of Science and Technology (KIST) and the Seoul National University, developed a new solution for the treatment of rheumatoid arthritis (RA).

RA is a chronic disease that, unfortunately, has no cure. The disease triggers a mix of troublesome symptoms like inflamed joints, harmful cytokines, and immune system imbalances, which work together to create a relentless cycle of worsening symptoms. While targeting some of these factors can provide short-term relief, others remain unresolved, leading to a frustrating cycle of remission and flare-ups.

One of the major hurdles in RA treatment is the inability to restore the immune system to its healthy state. This leaves the body unable to control the continuous production of harmful substances like reactive oxygen species (ROS) and inflammatory cytokines, leading to persistent inflammation and discomfort.

In essence, the ideal treatment for RA should not only provide immediate relief from inflammation and symptoms but also address the root cause by restoring the immune system to its normal, balanced state.

New nanoparticle-based system as a solution

The new platform involves immobilizing ceria nanoparticles (Ce NPs) onto mesenchymal stem cell-derived nanovesicles (MSCNVs). Both of these components can hinder different pathogenic factors, allowing them to work both individually and cooperatively to achieve a comprehensive treatment.

Ce NPs – can scavenge the overproduced ROS in RA-inflicted knee joints. They also induce polarization of M1 macrophages into M2, achieving immediate relief of inflammation and symptoms.

See also  Small Solutions for Big Problems in Drug Discovery and Delivery

MSCNVs – deliver immunomodulatory cytokines, which turn dendritic cells (DC) into tolerogenic dendritic cells (tDCs). This consequently generates regulatory T cells for long-term immune tolerance.

In short, this approach aims to bridge both innate and adaptive immunity to achieve both short-term pain relief, as well as convert the tissue environment into an immune-tolerant state to prevent the recurrence of symptoms.

Researchers confirmed the efficacy of this approach using a collagen-induced arthritis mouse model. The Ce-MSCNV system was able to comprehensively treat and prevent RA by simultaneously relieving the immediate and restoring T cell immunity. Supporting data suggest that improvement in conditions can be achieved after only a single-dose treatment.

The mice treated with the Ce-MSCNV combination fared far better compared to the ones only treated using the Ce NP or MSCNV group. This clearly demonstrates the synergy between anti-inflammation and immunomodulation and underlines the importance of the combined therapy for effective RA treatment. In addition, Ce-MSCNV administration prior to booster injection markedly reduced the incidence and severity of symptoms, supporting the prophylactic potential of these nanoparticles.

One of the hardest decisions in intractable disease therapy is determining how long the treatment should be carried on. For RA, it would not be appropriate to stop treatment just because the target marker is stabilized. A safer indicator should be that the innate and adaptive components of the collapsed immune system are normalized to protect the body.”

Koo Sagang, First Author

Koo believes that the strategy adopted by Ce-MSCNVs, where different treatment mechanisms work together, provides a unique advantage in this regard. Furthermore, she predicts that a similar approach would also be applicable to other intractable, inflammatory, and autoimmune diseases for this purpose. The components within the system may also be modified. For example, other catalysts for generating ROS or other cell-derived nanovesicles could be utilized depending on the types of diseases. Overall, this study proves the potential of a hybrid nanoparticle system for the comprehensive treatment of autoimmune disease and modulation of the immune system.

See also  Revolutionizing Sepsis Treatment with Innovative Blood Cleansing Technology

Source:

Institute for Basic Science

Journal reference:

Koo, S., et al. (2023). Ceria-vesicle nanohybrid therapeutic for modulation of innate and adaptive immunity in a collagen-induced arthritis model. Nature Nanotechnology. doi.org/10.1038/s41565-023-01523-y.

Source link

arthritis comprehensive developed nanoparticlebased rheumatoid System Treatment
Share. Facebook Twitter Pinterest LinkedIn Tumblr Email

Related Posts

Drug-loaded nanoparticles can enhance precision and safety of ultrasound tumor treatment

May 27, 2025

Nanoparticle treatment combined with radiation therapy significantly improves glioblastoma survival in mice

May 3, 2025

High-performance 3D-printed graphene composites developed for efficient ice control

May 2, 2025

Ultra-thin, flexible silicone nanosensor could have huge impact on brain injury treatment

April 22, 2025

Ultra-precision sensor technology developed for single-molecule detection

March 30, 2025

Nanogel drug delivery system shows promise for treating recurrent urinary tract infections

March 21, 2025

Comments are closed.

Top Articles
Research

Innovative Approaches to Predicting Nanostructure Formation

News

Fluorescence-guided photoimmunotherapy to manage peritoneal carcinomatosis

News

Silver-based micromotors that eliminate bacteria can move freely in aqueous media

Editors Picks

New insights show universal applicability of carbyne as a sensor

May 31, 2025

A new molecular model of bilayer graphene with higher semiconducting properties

May 31, 2025

5 Nanomaterial Innovations That Didn’t Deliver (Yet)

May 30, 2025

Scientists identify new 2D copper boride material with unique atomic structure

May 30, 2025
About Us
About Us

Your go-to source for the latest nanotechnology breakthroughs. Explore innovations, applications, and implications shaping the future at the molecular level. Stay informed, embrace the nano-revolution.

We're accepting new partnerships right now.

Facebook X (Twitter) Instagram Pinterest
Our Picks

“An Unparalleled Possibility” – Liquid Metals Shake Up Century-Old Chemical Engineering Processes

January 18, 2024

Novel fabrication technique takes transition metal telluride nanosheets from lab to mass production

April 12, 2024

New tech could give individuals increased control over their own exposure to harmful gases

June 15, 2024

Subscribe to Updates

Get the latest creative Nano Tech news from Elnano.com

© 2025 Elnano.com - All rights reserved.
  • Contact
  • Privacy Policy
  • Terms & Conditions

Type above and press Enter to search. Press Esc to cancel.

Cleantalk Pixel