Recently, Professor Di Sun’s group at Shandong University extended the salting-out method (commonly used to crystallize biological macromolecules, proteins, and DNA) to crystallize –COOH-functionalized AuNCs and obtained high-quality single crystals of three novel –COOH-functionalized Au25 nanoclusters, revealing the crystallographic structure of long-pursued –COOH-functionalized AuNCs.
This study not only demonstrates a facile approach for crystallizing –COOH-functionalized AuNCs, but also breaks the traditional perception of the structure of Au25(SR)18 and paves the way for investigating the correlation between their structures and properties.
“These new exciting results may be helpful for crystallizing protein-protected AuNCs, which have gained considerable attention in chemosensing or biosensing of cancer biomarkers, neurotransmitters, pathogenic microorganisms, biomolecules, pharmaceutical compounds, and immunoassays. This work will attract broad interest from the multi-disciplinary fields, including chemistry, biology, and materials,” Di Sun says.
The study is published in the journal Science Bulletin.
