Close Menu
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
What's Hot

Naturally derived nanoparticles show promise against cardiovascular and kidney disease

June 6, 2025

Ballistic electrons chart a new course for next-gen terahertz devices

June 6, 2025

‘Stealthy’ lipid nanoparticles give mRNA vaccines a makeover

June 5, 2025
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
  • News
  • Medical
  • Technology
  • Nanomaterials
  • Research
  • Blog
    • Nasiol.com
  • Contact
    • Tech7685@gmail.com
Facebook X (Twitter) Instagram
Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily Nanotech – Nanomaterials | Medical | Research | News Stories Updated Daily
Home»Medical»Amino acid nanoparticles show promise for cancer treatment
Medical

Amino acid nanoparticles show promise for cancer treatment

January 9, 2024No Comments4 Mins Read
Facebook Twitter Pinterest Telegram LinkedIn Tumblr WhatsApp Email
Amino acid nanoparticles show promise for cancer treatment
Share
Facebook Twitter LinkedIn Pinterest Telegram Email

Amino acids, such as tyrosine and tryptophan, are the fundamental building blocks that make up proteins. These biomolecules have different chemical groups on each end and side chain, and so, have the natural ability to form a chain through the formation of an amide (peptide) bond. However, such linkages are weak and easily degraded under physiological conditions. This is where the Fmoc-protected amino acids come into the picture.

In a new study now, a research team led by Dr. Eijiro Miyako, Associate Professor, Japan Advanced Institute of Science and Technology (JAIST) and Dr. Alberto Bianco and Dr. Cécilia Ménard-Moyon from the Centre National de la Recherche Scientifique (CNRS), France, employed ultraviolet light at 254 nm (leading to CBPUV nanoparticles) and riboflavin-mediated crosslinking at 365 nm (leading to CBPRibo nanoparticles) to crosslink the Fmoc-protected amino acids. “Amino acids being the building blocks of proteins have numerous advantages, such as better biocompatibility. Therefore, we wanted to create novel self-assembled amino acid-based nanoparticles which can be triggered through multiple mechanisms,” says Dr. Eijiro Miyako, explaining the motivation behind their research. The findings of this study are published in Small.

The self-assembled amino acids were stably crosslinked dimers of Fmoc-Tyr-OH (Tyrosine) and Fmoc-Trp-OH (Tryptophan). Doxorubicin, an anticancer drug, was subsequently loaded into the crosslinked amino acid nanoparticles. To increase the stability of the nanoparticles, the researchers used a tannic acid-Iron (Fe3+) complex (or TAF) as the outer layer of coating. This coating can degrade inside the cells through the glutathione enzymatic release or by pH difference in the tumor microenvironment. The tannic acid coating can be also used in photothermal anticancer therapy, where external light can increase the local temperature surrounding the cancer tissue, causing cancer cell death.

See also  Image-guided cancer treatment using biocompatible copper-based nanomaterials

The synthesized nanoparticles were then extensively studied for their structural integrity, stability, and drug release under different pH conditions. The functional profile, cellular uptake, and biocompatibility of self-assembled amino acid nanoparticles were then studied using cell culture techniques. Finally, the anticancer efficacy of synthesized nanoparticles was analyzed in tumor-bearing mice. The combined approach of chemotherapy, due to doxorubicin action, and photothermal therapy thanks to the tannic acid coating, showed excellent anticancer activity.

Post crosslinking, the amino acid-based nanoparticles showed notable changes in color, size, absorbance, fluorescence, and thermal stability. Furthermore, CBPUV exhibited superior stability after crosslinking, compared to CBPRibo. CBPUV also consistently maintained its structure, while CBPRibo showed partial disassembly, forming hollow spheres. Drug release study revealed minimal drug release under physiological pH (7.4), indicating that stable coating is crucial for in vivo delivery. At pH 5.5, incomplete coating degradation resulted in negligible drug release. However, the addition of glutathione (GSH) at pH 5.5 significantly boosted drug release by triggering TAF coating degradation, indicating GSH/pH responsiveness. The combined acidic and GSH treatment intensified coating degradation. This responsive behavior enables controlled drug release in specific physiological conditions. Furthermore, in vitro assessments revealed concentration-dependent cytotoxicity and improved efficacy in combined chemo/photothermal therapy. In vivo studies on tumor-bearing mice showcased significant tumor growth inhibition, indicating promising anticancer effects without observed side effects.

Sharing his concluding thoughts about the study findings, Dr. Miyako says, “Nanotechnology holds promise of transforming basic laboratory science into a powerful tool for combating complex diseases like cancer. We are optimistic that this pioneering research will advance, potentially evolving into cutting-edge cancer treatment technology ready for clinical trials within ten years.”

Going ahead, the development of these self-assembled amino acid nanoparticles can help in fighting critical issues such as multi-drug resistance in cancer and improve the overall efficacy of treatment outcomes.

See also  How activated gold nanoparticles reveal drug movement in the body

Source:

Japan Advanced Institute of Science and Technology

Journal reference:

Wang, T., et al. (2023). Photocrosslinked Co‐Assembled Amino Acid Nanoparticles for Controlled Chemo/Photothermal Combined Anticancer Therapy. Small. doi.org/10.1002/smll.202307337.

Source link

acid Amino cancer nanoparticles promise show Treatment
Share. Facebook Twitter Pinterest LinkedIn Tumblr Email

Related Posts

Naturally derived nanoparticles show promise against cardiovascular and kidney disease

June 6, 2025

New insights show universal applicability of carbyne as a sensor

May 31, 2025

Drug-loaded nanoparticles can enhance precision and safety of ultrasound tumor treatment

May 27, 2025

Biosensor uses pH-responsive DNA nanoswitches for highly sensitive bladder cancer detection in urine

May 24, 2025

Photoresponsive cages show promise for tunable supramolecular electronics

May 24, 2025

Targeted nanoparticles show promise for more effective antifungal treatments

May 23, 2025

Comments are closed.

Top Articles
News

Scientists use SERS technology to accurately monitor single-molecule diffusion behavior

News

Synthetic nanoparticle eyedrops help corneas heal after chemical or inflammatory damage

News

The New Dawn of Transition Metal Telluride Nanosheets

Editors Picks

Naturally derived nanoparticles show promise against cardiovascular and kidney disease

June 6, 2025

Ballistic electrons chart a new course for next-gen terahertz devices

June 6, 2025

‘Stealthy’ lipid nanoparticles give mRNA vaccines a makeover

June 5, 2025

Single-layer waveguide display uses achromatic metagratings for more compact augmented reality eyewear

June 5, 2025
About Us
About Us

Your go-to source for the latest nanotechnology breakthroughs. Explore innovations, applications, and implications shaping the future at the molecular level. Stay informed, embrace the nano-revolution.

We're accepting new partnerships right now.

Facebook X (Twitter) Instagram Pinterest
Our Picks

An evaluation of the main nanotechnology approaches to improve the therapeutic potential of polyphenols against cancer

August 12, 2023

How black silicon, a prized material used in solar cells, gets its dark, rough edge

January 19, 2024

Scalable graphene membranes could supercharge carbon capture

April 19, 2025

Subscribe to Updates

Get the latest creative Nano Tech news from Elnano.com

© 2025 Elnano.com - All rights reserved.
  • Contact
  • Privacy Policy
  • Terms & Conditions

Type above and press Enter to search. Press Esc to cancel.

Cleantalk Pixel